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Thomas A Comery Selected Research

alpha7 Nicotinic Acetylcholine Receptor

12/2011Preclinical assessment of an adjunctive treatment approach for cognitive impairment associated with schizophrenia using the alpha7 nicotinic acetylcholine receptor agonist WYE-103914/SEN34625.
6/2010Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).
5/2009Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders.
3/2009Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide).

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Thomas A Comery Research Topics

Disease

13Alzheimer Disease (Alzheimer's Disease)
07/2018 - 09/2005
9Cognitive Dysfunction
05/2014 - 04/2008
9Schizophrenia (Dementia Praecox)
11/2012 - 02/2009
3Central Nervous System Diseases (CNS Diseases)
11/2010 - 02/2009
2Mental Disorders (Mental Disorder)
01/2012 - 05/2010
2Weight Gain
01/2012 - 05/2009
2Memory Disorders (Memory Loss)
06/2008 - 04/2008
1AIDS-Related Complex (ARC)
05/2010
1Catalepsy
05/2009

Drug/Important Bio-Agent (IBA)

5Amyloid (Amyloid Fibrils)IBA
02/2012 - 09/2005
4Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA
05/2014 - 07/2009
4alpha7 Nicotinic Acetylcholine ReceptorIBA
12/2011 - 03/2009
3Antipsychotic Agents (Antipsychotics)IBA
01/2012 - 05/2009
3serotonin 6 receptorIBA
11/2010 - 02/2009
3LigandsIBA
11/2010 - 02/2009
3Amyloid beta-PeptidesIBA
01/2010 - 06/2008
2AntibodiesIBA
02/2012 - 01/2010
2Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
05/2010 - 11/2009
2Proteins (Proteins, Gene)FDA Link
02/2009 - 09/2005
2Amyloid Precursor Protein Secretases (beta-Secretase)IBA
02/2009 - 09/2005
1imidazoleIBA
07/2018
1SAM-760IBA
07/2018
1vabicaserinIBA
01/2012
11- (6- (4- fluorophenyl)pyridin- 3- yl)- 3- (4- piperidin- 1- ylbutyl)ureaIBA
12/2011
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
05/2010
1Dizocilpine Maleate (Dizocilpine)IBA
05/2010
1Glutamic Acid (Glutamate)FDA Link
05/2010
1Messenger RNA (mRNA)IBA
05/2010
1Peptides (Polypeptides)IBA
01/2010
1quinolineIBA
11/2009
1PapaverineIBA
11/2009
1Cholinergic Agents (Cholinergics)IBA
07/2009
1Clozapine (Clozaril)FDA LinkGeneric
05/2009
1Haloperidol (Haldol)FDA LinkGeneric
05/2009
1ApomorphineFDA Link
05/2009
15-morpholin-4-ylpentanoic acid (4-pyridin-3-ylphenyl)amideIBA
05/2009
11,2,3,4,8,9,10,10a- octahydro- 7bH- cyclopenta(b)(1,4)diazepino(6,7,1hj)indoleIBA
05/2009
1ApolipoproteinsIBA
06/2008
1GW 3965IBA
06/2008
1Serotonin (5 Hydroxytryptamine)IBA
04/2008
1Scopolamine (Hyoscine)FDA Link
04/2008

Therapy/Procedure

3Therapeutics
01/2012 - 02/2009
1Immunotherapy
01/2010